[PDF][PDF] Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
…, TT Schug, Q Xu, S Surapureddi, X Guo, X Li - Cell metabolism, 2009 - cell.com
Hepatic metabolic derangements are key components in the development of fatty liver, insulin
resistance, and atherosclerosis. SIRT1, a NAD + -dependent protein deacetylase, is an …
resistance, and atherosclerosis. SIRT1, a NAD + -dependent protein deacetylase, is an …
Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy
Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a
variety of tumors, but resistance during treatment is a major issue. In this review, we describe …
variety of tumors, but resistance during treatment is a major issue. In this review, we describe …
Single‐cell RNA sequencing in cancer research
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …
[HTML][HTML] SIRT1 deacetylates and positively regulates the nuclear receptor LXR
X Li, S Zhang, G Blander, GT Jeanette, M Krieger… - Molecular cell, 2007 - cell.com
The NAD + -dependent deacetylase Sir2 regulates life span in lower eukaryotes. The mammalian
ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, …
ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, …
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
Tumor immune escape is an important strategy of tumor survival. There are many mechanisms
of tumor immune escape, including immunosuppression, which has become a research …
of tumor immune escape, including immunosuppression, which has become a research …
Circular RNAs function as ceRNAs to regulate and control human cancer progression
Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization,
forming a complete ring structure. circRNA is more stable and conservative than linear …
forming a complete ring structure. circRNA is more stable and conservative than linear …
The role of microenvironment in tumor angiogenesis
…, B Xiang, M Zhou, C Guo, Z Zeng, G Li, X Li… - Journal of Experimental …, 2020 - Springer
Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …
and plays an important role in their growth, invasion, and metastasis. The tumor …
Neoantigen vaccine: an emerging tumor immunotherapy
Genetic instability of tumor cells often leads to the occurrence of a large number of mutations,
and expression of non-synonymous mutations can produce tumor-specific antigens called …
and expression of non-synonymous mutations can produce tumor-specific antigens called …
Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities
c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene)
family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the …
family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the …
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …