Tonic signaling of chimeric antigen receptor (CAR), ie, the spontaneous CAR activation in
the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-…

Background Consolidative allogeneic hematopoietic stem cell transplantation is a controversial
option for patients with relapsed/refractory acute lymphoblastic leukemia after chimeric …

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells
often display centrosome amplification. To maintain survival, cancer cells achieve bipolar …

To study the mechanism of acquired resistance to bortezomib, a new antitumor drug that is
the first therapeutic proteasome inhibitor, we established a series of bortezomib-resistant T …

Among cyclin-dependent kinase inhibitors that control the G1 phase in cell cycle, only p18
and p27 can negatively regulate haematopoietic stem cell (HSC) self-renewal. In this …

Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS).
However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. …

Measurable residual disease (MRD) is now considered as one of the most important prognostic
factors for B cell acute lymphoblastic leukemia (B-ALL), even for patients undergoing …

For successful transplantation using a haploidentical donor, it requires effective depletion of
T cells to reduce the risk of graft-versus-host disease (GvHD) and prevent serious GvHD. …

Nowadays, the most wildly used regimens for graft-versus-host disease (GvHD) prophylaxis
in haplo-hematopoietic stem cell transplantation (Haplo-HSCT) are based on in vivo T-cell …

The standard regimens for graft-versus-host disease (GvHD) prophylaxis in matched unrelated
donor (MUD) transplantation were based on antithymocyte globulin (ATG) in combination …