A tumour microenvironment imposes barriers to the passive diffusion of molecules, which
renders tumour penetration an unresolved obstacle to an effective anticancer drug delivery. …

CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …

A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation
of β‐lapachone and a reactive‐oxygen‐species (ROS)‐responsive doxorubicin (DOX) …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B-PDEAEA)…

The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of
conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted …

The destabilizing p53 cancer mutation Y220C creates a druggable surface crevice. We
developed a strategy exploiting halogen bonding for lead discovery to stabilize the mutant with …

(Figure 1a). Taking advantage of the high cytosolic esterase activity in HeLa cancer cells but
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …

Mounting evidence suggests that immunotherapies are a promising new class of anticancer
therapies. However, the immunosuppressive tumor microenvironment (TME), poor …

Cholesterol contributes to the structural basis of biological membranes and functions as a
signaling molecule, whose dysregulation has been associated with various human diseases. …