Excessive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) is an early and
invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the …

Progressive cerebral accumulation of amyloid β-protein (Aβ) is an early and invariant feature
of Alzheimer's disease. Little is known about how Aβ, after being secreted, is degraded and …

Maternally transmitted non–syndromic deafness was described recently both in pedigrees
with susceptibility to aminoglycoside ototoxicity and in a large Arab–Israeli pedigree. Because …

Humans use rich natural language to describe and communicate visual perceptions. In
order to provide natural language descriptions for visual content, this paper combines two …

Clinical and epidemiological studies have found that type 2 diabetes, and hyperinsulinaemia,
increased the risk of developing Alzheimer's disease (AD) in the elderly. The link between …

Predicting clinically significant drug interactions during drug development is a challenge for
the pharmaceutical industry and regulatory agencies. Since the publication of the US Food …

To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma
(HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in …

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs)
and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …

It is well documented that the traditional Fenton reagent (ie, the combination of Fe(II) and H 2
O 2 ) produces hydroxyl radical ( • OH) under acidic conditions, while at near-neutral pH the …

High-valent iron(IV)–oxo complexes are of great significance as reactive intermediates implicated
in diverse chemical and biological systems. The aqueous iron(IV)–oxo complex (Fe aq …