Blood formation is believed to occur through stepwise progression of haematopoietic stem
cells (HSCs) following a tree-like hierarchy of oligo-, bi-and unipotent progenitors. However, …

Single-cell genomics technology has transformed our understanding of complex cellular
systems. However, excessive cost and a lack of strategies for the purification of newly identified …

Clonal evolution is believed to be a main driver for progression of various types of cancer
and implicated in facilitating resistance to drugs. However, the hierarchical organization of …

Background Aspergillus spp. induce elevated levels of several cytokines. It remains
unknown whether these cytokines hold value for clinical routine and enhance diagnostic …

In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become
increasingly important for diagnosis of invasive aspergillosis (IA). Whether or not these …

Cancer stem cells drive disease progression and relapse in many types of cancer. Despite
this, a thorough characterization of these cells remains elusive and with it the ability to …

Background The Aspergillus Galactomannan Lateral Flow Assay (LFA) is a rapid test for the
diagnosis of invasive aspergillosis (IA) that has been almost exclusively evaluated in …

Hematopoietic stem and progenitor cells (HSPCs) are responsible for the production of blood
and immune cells. Throughout life, HSPCs acquire oncogenic aberrations that can cause …

Background Over the past decades, US Congress enabled the US Food and Drug Administration
(FDA) to facilitate and expedite drug development for serious conditions filling unmet …

Lung cancer remains the leading cause of cancer-associated mortality worldwide, but with
the emergence of oncogene targeted therapies, treatment options have tremendously …