Authentic bovine embryonic stem (ES) cell lines have not been established despite progress
made for more than two decades. Isolation and culture of primary ES cell colonies are the …

Background Different genomic characterization in urothelial carcinoma (UC) by site of origin
may imply contrasting therapeutic opportunities and pathogenetic mechanisms. The aim of …

Mammalian parthenogenetic embryos are not viable and die because of defects in placental
development and genomic imprinting. Parthenogenetic ESCs (pESCs) derived from …

The conventional method for producing embryonic stem (ES) cell-derived knockout or
transgenic mice involves injection of ES cells into normal, diploid blastocysts followed by several …

Anaplastic lymphoma kinase ( ALK ) fusions have been recognized as a therapeutic target
in non‐small cell lung cancer ( NSCLC ). However, molecular signatures and clinical …

Objective To determine the effects of Benzo(a)pyrene (BaP) on the development of early
preimplantation embryo by exposure to physiologic concentrations of BaP based on a previous …

Spermatids undergo the final steps of maturation during spermiogenesis, a process that
necessitates extensive rearrangement of organelles such as the mitochondria. Male infertility …

Bladder cancer is the most common type of genitourinary cancer in China, with an estimated
80,500 new cases and 32,900 related deaths in 2015 alone (Chen et al., 2016). Unlike …

Background Homologous recombination (HR) repair (HRR) has been indicated to be a
biomarker for immunotherapy, chemotherapy, and poly‐ADP ribose polymerase inhibitors …

Objective The incidence of early stage multiple primary lung cancer (MPLC) has been
increasing in recent years, while the ideal strategy for its diagnosis and treatment remains …