To follow the revision of the fourth edition of WHO classification and the recent progress on
the management of diffuse gliomas, the joint guideline committee of Chinese Glioma …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization of …

Gliomas are the most common and malignant intracranial tumors in adults. Recent studies
have revealed the significance of functional genomics for glioma pathophysiological studies …

Now, numerous exciting findings have been yielded in the field of energy metabolism within
glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for …

… How to cite this article: Chai R, Fang S, Pang B, Liu Y, Wang Y, Zhang W, Jiang T. Molecular
pathology and clinical … Ruichao Chai and Shengyu Fang contributed equally to this work. …

Astrocyte activation is a hallmark of central nervous system injuries resulting in glial scar
formation (astrogliosis). The activation of astrocytes involves metabolic and morphological …

Lipid metabolism reprogramming plays important role in cell growth, proliferation,
angiogenesis and invasion in cancers. However, the diverse lipid metabolism programmes and …

The methylation status of the promoter of MGMT gene is a crucial factor influencing clinical
decision-making in patients with gliomas. MGMT pyrosequencing results are often …

Understanding the racial specificities of diseases—such as adult diffuse glioma, the most
common primary malignant tumor of the central nervous system—is a critical step toward …

Transcriptomic data derived from bulk sequencing have been applied to delineate the tumor
microenvironment (TME) and define immune subtypes in various cancers, which may …