We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1
, 2 , 3 of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (…

Background and Objectives Previous studies have shown that betaine prevents alcohol-induced
liver injury and improves liver function. The purpose of this study was to investigate the …

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated
damaged mitochondria, which are associated with impaired mitophagy, contribute to …

Background Histone deacetylase 6 (HDAC6) has been considered as an important regulator
in the development of inflammatory diseases. However, the mechanism of HDAC6 in …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide.
Recent studies reported that lncRNA LINC00473 (LNC473) was involved in cancer …

AIM To investigate whether SGs could protect hepatocytes from hypoxia-induced damage
during acute liver failure (ALF) by reducing endoplasmic reticulum stress (ERS) mediated …

Genome-wide association studies have identified susceptibility loci for esophageal
squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide …

Introduction Liver disease is common and often life-threatening. Sinomenine (SIN) is an
active ingredient extracted from Sinomenium acutum. This study investigated the protective …

In this study, we induced an acute-on-chronic liver failure (ACLF) model by human serum
albumin (HSA), d-galactosamine (d-Gal) and lipopolysaccharide (LPS) in rats. Anti-TNF-α …

AIM: To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses,
assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models …