The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor family.
It is distributed in various tissues of the human body and is involved in regulating the …

Synovial tissue hyperplasia is a major cause of bone damage in rheumatoid arthritis (RA).
Over-proliferation and secretion of cytokines of fibroblast-like synoviocytes (FLSs) are key …

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently
diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with …

DYRK1A is considered a potential cancer therapeutic target, but the role of DYRK1A in
NSCLC oncogenesis and treatment requires further investigation. In our study, high DYRK1A …

Purpose Pancreatic carcinoma is one of the most deadliest types of cancer, and relatively
insensitive to the currently available chemotherapy. Thus, the discovery of novel therapeutic …

Objective: Mcl-1 overexpression confers acquired resistance to Bcl-2 inhibitors in non-small
cell lung cancer (NSCLC), but no direct Mcl-1 inhibitor is currently available for clinical use. …

Background Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases,
while metastasis is considered the leading cause of HCC-related death. However, the …

Hypoxia promotes drug resistance and induces the expression of hypoxia inducible factor (HIF)‑1α
in liver cancer cells. However, to date, no selective HIF‑1α inhibitor has been …

Regorafenib has been approved to treat patients who have HCC progression after sorafenib
failure, however, regorafenib also faces the risk of drug resistance and subsequent …

Hypoxia promotes HCC progression and therapy resistance, and there is no systemic
treatment for HCC patients after sorafenib resistance. Thus, it is urgent to develop potential …