[PDF][PDF] Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients

…, L Yu, J Yan, G Diao, F Meng, C Bai, P Mao, Y Yu… - Immunity, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide public health
threat. However, little is known about its hallmarks compared to other infectious diseases. …

[HTML][HTML] The advanced development of molecular targeted therapy for hepatocellular carcinoma

T Yan, L Yu, N Zhang, C Peng, G Su… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), one of the most common malignant tumors in China,
severely threatens the life and health of patients. In recent years, precision medicine, clinical …

Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China

…, L Yu, Z Wang, Z Hong, Z Xiao, Q Xi, D Zhao, P Yu… - Medrxiv, 2020 - medrxiv.org
Background SARS-CoV-2-caused coronavirus disease (COVID-19) is posing a large
casualty. The features of COVID-19 patients with and without pneumonia, SARS-CoV-2 …

Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma …

Y Zhang, X Guo, L Xiong, L Yu, Z Li, Q Guo, Z Li, B Li… - Molecular cancer, 2014 - Springer
Background Our previous study identified AKT1, AKT2 and AKT3 as unfavorable prognostic
factors for patients with hepatocellular carcinoma (HCC). However, limited data are …

Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients

…, J Pan, K Hu, M Guan, L Huo, J Shi, L Yu… - Hepatology …, 2023 - Springer
Introduction Combining lenvatinib with a programmed cell death protein-1 (PD-1) inhibitor
has been explored for the treatment of un-resectable hepatocellular carcinoma (uHCC). This …

Preclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation

W Chen, Z Ma, L Yu, X Mao, N Ma, X Guo… - … & Molecular Medicine, 2022 - nature.com
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC).
Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART …

Artesunate sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy

Z Ma, W Chen, Y Liu, L Yu, X Mao, X Guo, F Jiang… - Autophagy, 2024 - Taylor & Francis
Sorafenib is the most widely used first-line drug for the treatment of the advanced hepatocellular
carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy…

FOXO3a Alleviates the Inflammation and Oxidative Stress via Regulating TGF-β and HO-1 in Ankylosing Spondylitis

S Xu, X Zhang, Y Ma, Y Chen, H Xie, L Yu… - Frontiers in …, 2022 - frontiersin.org
This study aimed to investigate whether Forkhead box O3a (FOXO3a) modulates inflammation
and oxidative stress in ankylosing spondylitis (AS). We applied bioinformatics analysis, …

Identification of GRB2 and GAB1 coexpression as an unfavorable prognostic factor for hepatocellular carcinoma by a combination of expression profile and network …

Y Zhang, Z Li, M Yang, D Wang, L Yu, C Guo, X Guo… - PloS one, 2013 - journals.plos.org
Aim To screen novel markers for hepatocellular carcinoma (HCC) by a combination of
expression profile, interaction network analysis and clinical validation. Methods HCC significant …

[HTML][HTML] Short-term effects of ambient temperature and pollutants on the mortality of respiratory diseases: A time-series analysis in Hefei, China

M Shao, L Yu, C Xiao, J Deng, H Yang, W Xu… - Ecotoxicology and …, 2021 - Elsevier
Background The air pollution has become an important environmental health problem due to
its adverse health effect. The objective of this study was to investigate the effects of ambient …