The ability to detect single protein molecules 1 , 2 in blood could accelerate the discovery
and use of more sensitive diagnostic biomarkers. To detect low-abundance proteins in blood, …

Implementation of amyloid biomarkers in clinical practice would be accelerated if such
biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …

Objective: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is
related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] …

We report a method for combining the detection of single molecules (digital) and an ensemble
of molecules (analog) that is capable of detecting enzyme label from 10 −19 M to 10 −13 M…

Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and
are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known …

Glial fibrillary acidic protein (GFAP), microtubule-associated protein tau, and amyloid β peptide
(Aβ42) have been proposed as diagnostic and prognostic biomarkers in traumatic brain …

We have developed a method that enables the multiplexed detection of proteins based on
counting single molecules. Paramagnetic beads were labeled with fluorescent dyes to create …

Objectives To determine whether a panel of blood-based biomarkers can discriminate between
patients with suspected mild traumatic brain injury (mTBI) with and without neuroimaging …

Introduction Blood protein analysis of total tau (t-tau) may be a practical screening biomarker
for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated …

Objective We tested the hypothesis that plasma neurofilament light chain (NfL) identifies
asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)–causing mutations …