User profiles for Lan Huang

Lan Huang

Professor of Physiology & Biophysics, University of California, Irvine
Verified email at uci.edu
Cited by 16043

[HTML][HTML] Oxidative stress-mediated regulation of proteasome complexes

CT Aiken, RM Kaake, X Wang, L Huang - Molecular & Cellular Proteomics, 2011 - ASBMB
Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are generated …

Baseline serum uric acid level as a predictor of cardiovascular disease related mortality and all-cause mortality: a meta-analysis of prospective studies

G Zhao, L Huang, M Song, Y Song - Atherosclerosis, 2013 - Elsevier
Objective Serum uric acid (SUA) levels have been used to predict cardiovascular and all-cause
mortality event, but the data have yielded conflicting results. We investigated whether …

[HTML][HTML] Cross-linking mass spectrometry (XL-MS): An emerging technology for interactomics and structural biology

C Yu, L Huang - Analytical chemistry, 2018 - ncbi.nlm.nih.gov
Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

M Ehrlich, MA Gama-Sosa, LH Huang… - Nucleic acids …, 1982 - academic.oup.com
Abstract Analysis of the total base composition of DNA from seven different normal human
tissues and eight different types of homogeneous human cell populations revealed …

[HTML][HTML] The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

…, S Kang, J Wu, P Datta, M McCormick, L Huang… - Nature …, 2010 - nature.com
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which
triggers production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18. We …

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

L Huang, E Kinnucan, G Wang, S Beaudenon… - Science, 1999 - science.org
The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation
of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, …

An elliptic spatial scan statistic

M Kulldorff, L Huang, L Pickle… - Statistics in medicine, 2006 - Wiley Online Library
The spatial scan statistic is commonly used for geographical disease cluster detection,
cluster evaluation and disease surveillance. The most commonly used shape of the scanning …

Particle swarm optimization for traveling salesman problem

KP Wang, L Huang, CG Zhou… - Proceedings of the 2003 …, 2003 - ieeexplore.ieee.org
This paper proposes a new application of particle swarm optimization for traveling salesman
problem. We have developed some special methods for solving TSP using PSO. We have …

[HTML][HTML] Stress‐inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

…, SG Jachieri, A Burlingame, L Huang… - The EMBO …, 2002 - embopress.org
Prions are composed of an isoform of a normal sialoglycoprotein called PrP c, whose
physiological role has been under investigation, with focus on the screening for ligands. Our group …

Patterns of protein synthesis and tolerance of anoxia in root tips of maize seedlings acclimated to a low-oxygen environment, and identification of proteins by mass …

WWP Chang, L Huang, M Shen, C Webster… - Plant …, 2000 - academic.oup.com
Tolerance of anoxia in maize root tips is greatly improved when seedlings are pretreated
with 2 to 4 h of hypoxia. We describe the patterns of protein synthesis during hypoxic …