Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer
Hypoxia-inducible factor 1α (HIF1α) has emerged as a promising new target for pancreatic
cancer treatment over the past decade. High expression of HIF-1α increases the drug …
cancer treatment over the past decade. High expression of HIF-1α increases the drug …
[HTML][HTML] Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBV-induced
gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly …
gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly …
Interleukin 35 expression correlates with microvessel density in pancreatic ductal adenocarcinoma, recruits monocytes, and promotes growth and angiogenesis of …
…, T Zhao, X Wang, H Wang, S Gao, S Yang, J Hao… - Gastroenterology, 2018 - Elsevier
Background & Aims Cells of the monocyte lineage contribute to tumor angiogenesis. Interleukin
35 (IL35) is a member of the IL12 family produced by regulatory, but not effector, T cells. …
35 (IL35) is a member of the IL12 family produced by regulatory, but not effector, T cells. …
Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer
Elevated mitochondrial calcium uptake in PDAC promotes metastasis but exposes cystine
addiction and ferroptosis sensitivity that could be targeted to improve pancreatic cancer …
addiction and ferroptosis sensitivity that could be targeted to improve pancreatic cancer …
[HTML][HTML] Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma
…, S Bian, X Wu, Y Zhang, Y Liu, D Fu, L Wen, J Hao… - Cell Discovery, 2022 - nature.com
The epigenomic abnormality of pancreatic ductal adenocarcinoma (PDAC) has rarely been
investigated due to its strong heterogeneity. Here, we used single-cell multiomics …
investigated due to its strong heterogeneity. Here, we used single-cell multiomics …
[HTML][HTML] IL-37/STAT3/HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer
…, C Huang, X Wang, S Gao, J Liu, S Yang, J Hao - Theranostics, 2020 - ncbi.nlm.nih.gov
Human interleukin (IL)-37 is a member of the IL-1 family with potent anti-inflammatory and
immunosuppressive properties. Previously, it has been reported that IL-37 suppresses tumor …
immunosuppressive properties. Previously, it has been reported that IL-37 suppresses tumor …
[HTML][HTML] Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer
…, R Cheng, N Zhao, J Meng, B Sun, J Hao - Cancer Biology & …, 2021 - ncbi.nlm.nih.gov
Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal
adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. …
adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. …
[HTML][HTML] ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis
…, X Wang, S Gao, Z Liu, S Yang, C Gao, J Hao - British Journal of …, 2022 - nature.com
Background Desmoplastic stroma, a feature of pancreatic ductal adenocarcinoma (PDAC),
contains abundant activated pancreatic stellate cells (PSCs). How PSCs promote PDAC …
contains abundant activated pancreatic stellate cells (PSCs). How PSCs promote PDAC …
[PDF][PDF] A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
…, X Shen, J Zhang, J Chen, Y Yang, L Liu, X Li, J Hao… - Molecular Cell, 2022 - cell.com
The efficiency of homologous recombination (HR) in the repair of DNA double-strand breaks
(DSBs) is closely associated with genome stability and tumor response to chemotherapy. …
(DSBs) is closely associated with genome stability and tumor response to chemotherapy. …
Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy
…, T Ji, X Wang, X Yang, Y Zhang, K Cheng, S Liu, J Hao… - Biomaterials, 2016 - Elsevier
Immunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune
response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-…
response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-…