Cancers may arise from rare self-renewing tumor-initiating cells (T-IC). However, how T-IC
self renewal, multipotent differentiation, and tumorigenicity are maintained remains obscure. …

Carcinoma-associated fibroblasts (CAFs) are abundant and heterogeneous stromal cells in
tumor microenvironment that are critically involved in cancer progression. Here, we …

NF-κB is a critical link between inflammation and cancer, but whether long non-coding
RNAs (lncRNAs) regulate its activation remains unknown. Here, we identify an NF-KappaB …

The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and
tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these two …

Importance The beneficial role of immunotherapy and the clinical relevance of current
biomarkers in non–small cell lung cancer (NSCLC) remain inconclusive; thus, appropriate …

Colorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis
has been extensively explored over the past decades. Recently, microorganisms in the …

Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis,
but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce …

Chemotherapy-induced neutropenia (CIN) is a potentially fatal and common complication in
myelosuppressive chemotherapy. The timing and grade of CIN may play prognostic and …

Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor
receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 …

Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to escape
immunological destruction. We demonstrated that tumor-specific cytotoxic T lymphocytes (…