With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

The concept of cancer stem cells (CSCs) proposes that solely CSCs are capable of generating
tumor metastases. However, how CSCs maintain their invasion and migration abilities, …

Anti–PD-1/PD-L1 therapy, either by anti–PD-1 antibody or anti–PD-L1 antibody, has efficacy
by reinvigorating tumor-infiltrating CD8 + T cells in a subset of patients with cancer, but it …

During the course of tumorigenesis and subsequent metastasis, malignant cells gradually
diversify and become more heterogeneous. Consequently, the tumor mass might be infiltrated …

Tumor-associated myeloid cells (TAMCs) are among the most important immune cell
populations in the tumor microenvironment, and play a significant role on the efficacy of immune …

IL-17, which exerts strong pro-inflammatory effects, has emerged as an important mediator
in inflammation-associated cancer. However, the characteristics of IL-17-producing cells, the …

Cancer stem cells (CSCs) are well known for their self-regeneration and tumorigenesis
potential. In addition, the multi-differentiation potential of CSCs has become a popular issue and …

The Tibetan Plateau is the highest and one of the most demanding environments ever inhabited
by humans. We investigated the timing and mechanisms of its initial colonization at the …

Despite the unprecedented success of immune checkpoint inhibitors (ICIs) as anti-cancer
therapy, it remains a prevailing clinical need to identify additional mechanisms underlying ICI …

Distant metastasis is the major cause of cancer-related deaths in patients with lung
adenocarcinoma (LAD). Emerging evidence reveals that miRNA is critical for tumor metastasis. miR-…