The positioning of nucleosomes along chromatin has been implicated in the regulation of
gene expression in eukaryotic cells, because packaging DNA into nucleosomes affects …

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not been …

Imaging the transcriptome in situ with high accuracy has been a major challenge in single-cell
biology, which is particularly hindered by the limits of optical resolution and the density of …

Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2)
has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic …

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function.
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …

Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …

Electrocatalysis by atomic catalysts is a major focus of chemical and energy conversion effort.
Although transition-metal-based bulk electrocatalysts for electrochemical application on …

Many human cancers are resistant to immunotherapy, for reasons that are poorly understood.
We used a genome-scale CRISPR-Cas9 screen to identify mechanisms of tumor cell …

Genome-wide association studies (GWASs) have ascertained numerous trait-associated
common genetic variants, frequently localized to regulatory DNA. We found that common …

Both the dendritic cell receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR
bind human immunodeficiency virus and enhance infection. However, biochemical …