[HTML][HTML] Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Y Wang, D Zhang, G Du, R Du, J Zhao, Y Jin, S Fu… - The lancet, 2020 - thelancet.com
Background No specific antiviral drug has been proven effective for treatment of patients
with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside …

Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects

J Zhang, C Wu, L Gao, G Du, X Qin - Advances in Pharmacology, 2020 - Elsevier
Decoctions prepared from the roots of Astragali Radix are known as “Huangqi” and are
widely used in traditional Chinese medicine for treatment of viral and bacterial infections, …

[HTML][HTML] The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

…, Q Lv, F Li, H Liu, B Hou, X Peng, Y Lu, G Du - Biochemical …, 2021 - Elsevier
Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb
with multiple pharmacological activities, including the broad anti-virus effects. In this paper, …

Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile

…, G He, X Mu, T Zhang, X Li, J Hu, B Xu, G Du - Neuroscience …, 2008 - Elsevier
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic
neurons as seen in Parkinson's disease (PD). Oxidative stress has been implicated in the …

Skeletal muscle atrophy: From mechanisms to treatments

…, N Li, W Jia, N Wang, M Liang, X Yang, G Du - Pharmacological …, 2021 - Elsevier
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic homeostasis,
and thermogenesis. It makes up approximately 40% of the total body weight and 50% of …

[HTML][HTML] The biology, function, and applications of exosomes in cancer

…, X Zheng, Y Yang, W Fu, J Yi, J Wang, G Du - … Pharmaceutica Sinica B, 2021 - Elsevier
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon
fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins…

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

X Mu, G He, Y Cheng, X Li, B Xu, G Du - Pharmacology Biochemistry and …, 2009 - Elsevier
Baicalein, a flavonoid obtained from the root of Chinese medicinal herb Scutellaria baicalensis,
has been shown to exert a protective effect on neurons against several neuronal insults. …

The strategies and techniques of drug discovery from natural products

…, T Yuan, W Li, W Zhang, B Hou, Y Lu, G Du - Pharmacology & …, 2020 - Elsevier
Natural products have been the main sources of new drugs. The different strategies have
been developed to find the new drugs based on natural products. The traditional and ethic …

In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives

M Zu, F Yang, W Zhou, A Liu, G Du, L Zheng - Antiviral research, 2012 - Elsevier
The theaflavins fraction (TF80%, with a purity of 80%) and three theaflavin (TF) derivatives
from black tea have been found to exhibit potent inhibitory effects against influenza virus in …

Apolipoproteins and cancer

…, J Yi, W Li, X Zheng, J Liu, J Wang, G Du - Cancer …, 2019 - Wiley Online Library
The role of apolipoproteins in cardiovascular disease has been well investigated, but their
participation in cancer has only been explored in a few published studies which showed a …