Polymorphisms in microRNA targets: a gold mine for molecular epidemiology
MicroRNAs are non-coding small RNAs that regulate gene expression by Watson–Crick
base pairing to target messenger RNA (mRNA). They are involved in most biological and …
base pairing to target messenger RNA (mRNA). They are involved in most biological and …
[HTML][HTML] Histone deacetylase 6 in cancer
T Li, C Zhang, S Hassan, X Liu, F Song, K Chen… - Journal of hematology & …, 2018 - Springer
Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the …
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the …
[HTML][HTML] Assessment of performance of the Gail model for predicting breast cancer risk: a systematic review and meta-analysis with trial sequential analysis
X Wang, Y Huang, L Li, H Dai, F Song, K Chen - Breast Cancer Research, 2018 - Springer
Background The Gail model has been widely used and validated with conflicting results.
The current study aims to evaluate the performance of different versions of the Gail model by …
The current study aims to evaluate the performance of different versions of the Gail model by …
[HTML][HTML] Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer
Background Most (70%) epithelial ovarian cancers (EOCs) are diagnosed late. Non-invasive
biomarkers that facilitate disease detection and predict outcome are needed. The …
biomarkers that facilitate disease detection and predict outcome are needed. The …
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
…, C Menin, J Martinez, A Hadjisavvas, L Song… - Nature …, 2020 - nature.com
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of …
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of …
Diagnostic classification of cancers using extreme gradient boosting algorithm and multi-omics data
B Ma, F Meng, G Yan, H Yan, B Chai, F Song - Computers in biology and …, 2020 - Elsevier
Accurate diagnostic classification of cancers can greatly help physicians to choose surveillance
and treatment strategies for patients. Following the explosive growth of huge amounts of …
and treatment strategies for patients. Following the explosive growth of huge amounts of …
Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types
…, EL Goode, E Khusnutdinova, E Høgdall, F Song… - Cancer discovery, 2016 - AACR
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic
basis, but this has not been investigated systematically by genome-wide association (GWA) …
basis, but this has not been investigated systematically by genome-wide association (GWA) …
Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification
L Zhang, Y Liu, F Song, H Zheng… - Proceedings of the …, 2011 - National Acad Sciences
We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3),
which encodes a large protein that forms a calcium channel, is important for the growth, …
which encodes a large protein that forms a calcium channel, is important for the growth, …
Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy
Gastric cancer (GC) is a highly heterogeneous disease. To identify potential clinically
actionable therapeutic targets that may inform individualized treatment strategies, we performed …
actionable therapeutic targets that may inform individualized treatment strategies, we performed …