Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized
by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …

A network of communicating tumour cells that is connected by tumour microtubes mediates
the progression of incurable gliomas. Moreover, neuronal activity can foster malignant …

Both the perivascular niche (PVN) and the integration into multicellular networks by tumor
microtubes (TMs) have been associated with progression and resistance to therapies in …

Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas,
including glioblastomas. We recently discovered ultralong (>10 to hundreds of microns) …

Objective To visualize and quantify differences of microstructural nerve damage in distal
symmetric diabetic neuropathy (DPN) between type 1 diabetes (T1D) and type 2 diabetes (T2D)…

Mitochondrial networks in cardiac myocytes under oxidative stress show collective (cluster)
behavior through synchronization of their inner membrane potentials (ΔΨ m ). However, it is …

Objectives Despite the extensive number of publications in the field of radiomics, radiomics
algorithms barely enter large-scale clinical application. Supposedly, the low external …

Aims/hypothesis The individual risk of progression of diabetic peripheral neuropathy is difficult
to predict for each individual. Mutations in proteins that are responsible for the process of …

Importance Lowering serum cholesterol levels is a well-established treatment for dyslipidemia
in patients with type 2 diabetes (T2D). However, nerve lesions in patients with T2D …

Background Nerve damage in diabetic neuropathy (DN) is assumed to begin in the distal
legs with a subsequent progression to hands and arms at later stages. In contrast, recent …