Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide.
In contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

[PDF][PDF] Phase 1 clinical trial to assess safety and efficacy of NY-ESO-1-specific TCR T cells in HLA-A∗ 02: 01 patients with advanced soft tissue sarcoma

Q Pan, D Weng, J Liu, Z Han, Y Ou, B Xu, R Peng… - Cell Reports …, 2023 - cell.com
New York esophageal squamous cell carcinoma-1 (NY-ESO-1)-specific T cell receptor (TCR)
T cell therapy is effective in tumors with NY-ESO-1 expression, but a safe and effective TCR…

[HTML][HTML] LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival

Y Que, Z Fang, Y Guan, W Xiao, B Xu… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Objective To elucidate the role and prognostic significance of lymphocyte activation-gene-3 (LAG-3)
in soft tissue sarcoma (STS). Methods The expression of LAG-3 in patient and …

[HTML][HTML] Anlotinib as a maintenance treatment for advanced soft tissue sarcoma after first-line chemotherapy (ALTER-S006): a multicentre, open-label, single-arm …

B Xu, Q Pan, H Pan, H Li, X Li, J Chen, D Pang… - …, 2023 - thelancet.com
Background No standard maintenance treatment has been obtained to prolong the response
duration of soft tissue sarcoma (STS) after first-line chemotherapy. In this study, we aimed …

Chimeric antigen receptor‐modified T‐cell therapy for platelet‐derived growth factor receptor α‐positive rhabdomyosarcoma

W Xiao, J Wang, X Wen, B Xu, Y Que, K Yu, L Xu… - Cancer, 2020 - Wiley Online Library
Background New immunotherapeutic approaches are urgently needed for metastatic
rhabdomyosarcoma, which is associated with poor survival and unsatisfactory treatment outcomes. …

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

B Xu, H Qiu, B Ou, S Chen, D Du, Y Liu, X Zhang… - Oral …, 2023 - Wiley Online Library
Objectives To explore the predictive value of inflammatory‐nutritional score (INS) and a
nomogram for survivals in head and neck soft tissue sarcoma (HNSTS) patients with negative …

Phase I clinical trial to assess safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of NY-ESO-1–specific TCR T-cells (TAEST16001) in HLA-A* 02 …

X Zhang, D Weng, Q Pan, J Liu, Z Han, R Peng, B Xu… - 2022 - ascopubs.org
11502 Background: NY-ESO-1 is a cancer/testis antigen with expression in a wide range of
tumor types. TAEST16001 cells are genetically engineered autologous T cells that express …

[HTML][HTML] Comparison of the MAID (AI) and CAV/IE regimens with the predictive value of cyclic AMP-responsive element-binding protein 3 like protein 1 (CREB3L1) in …

W Xiao, Y Liang, Y Que, J Li, R Peng, B Xu… - Journal of …, 2019 - ncbi.nlm.nih.gov
Background: Palliative chemotherapy is currently the first-line treatment for advanced soft
tissue sarcoma. The purpose of this study was to compare the efficacies of the MAID (AI) and …

A phase II study of surufatinib in patients with osteosarcoma and soft tissue sarcoma who have experienced treatment failure with standard chemotherapy.

X Zhang, Q Pan, R Peng, B Xu, D Hong, Y Que - 2023 - ascopubs.org
e23540 Background: Surufatinib is a multi-targeted, small-molecule tyrosine kinase inhibitor
(TKI) that shows strong inhibitory effect on the activity of VEGFR-1, 2, 3, FGFR1 and CSF-1R…

A phase II clinical trial of chidamide in combination with toripalimab in patients with advanced soft tissue sarcoma.

X Zhang, R Peng, Q Pan, B Xu, D Hong, Y Que - 2023 - ascopubs.org
11566 Background: Chidamide is an oral subtype-selective histone deacetylase inhibitor
which is effective on the patients with hematological tumors and reported to enhance the …