In senescent cells, a DNA damage response drives not only irreversible loss of replicative
capacity but also production and secretion of reactive oxygen species (ROS) and bioactive …

Biomedical research requires both in vitro and in vivo studies in order to explore disease
processes or drug interactions. Foundational investigations have been performed at the cellular …

Purpose Up-regulation of lactate dehydrogenase LDHA, is a frequent event in human
malignancies and relate to poor postoperative outcome. In the current study we examined the …

Aldehyde dehydrogenase 3A1 (ALDH3A1) oxidizes medium-chain aldehydes to their
corresponding carboxylic acids. It is expressed at high rates in the human cornea, where it has …

Aims Lung cancer is one of the main causes of cancer-related deaths worldwide and
radiotherapy is a major treatment of choice. However, radioresistance is a main reason for …

Lipid metabolism reprogramming is one of the adaptive events that drive tumor development
and survival, and may account for resistance to chemotherapeutic drugs. Perilipins are …

Simple Summary The role of Inducible Nitric Oxygen Synthase (iNOS) in the progression of
human malignancies is obscure. We studied the expression patterns of iNOS in non-small-…

Objective : Cancer cell radioresistance is a stumbling block in radiation therapy. The activity
in the nuclear factor kappa B (NFκB) pathway correlates with anti-apoptotic mechanisms and …

Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer
therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases …

Faithful chromosome segregation during cell division requires accurate mitotic spindle
formation. As mitosis occurs rapidly within the cell cycle, the proteins involved in mitotic spindle …