Understanding tumor metabolism is important for the development of anticancer therapies.
Immunohistochemical evaluation of colorectal adenocarcinomas showed that cancer cells …

Purpose : Hypoxia-inducible factors HIF1α and HIF2α (HIFαs) regulate the expression of a
variety of genes encoding proteins related to angiogenesis and to anaerobic metabolism of …

Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is
involved in the reversible metabolism of the carbon dioxide to carbonic acid. Up-regulation of …

Neutrophils are involved in the pathophysiology of infracted coronary arteries in STEMI via
NET structures. Platelets, activated by thrombin, are required for NET formation, while the …

Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular
response to hypoxia. Because the efficacy of photodynamic therapy (PDT) is dependent on …

Neutrophil activation by inflammatory stimuli and the release of extracellular chromatin
structures (neutrophil extracellular traps – NETs ) have been implicated in inflammatory disorders…

Purpose Randomized controlled trials have generally shown a benefit from accelerated
radiotherapy in head and neck squamous cell carcinoma (HNSCC). However, the large …

Different vascular endothelial growth factor (VEGF) gene polymorphisms have been shown
to result in different VEGF gene responsiveness to various stimuli and different capacity for …

Objectives Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is
characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events …

Lactate dehydrogenase 5 (LDH5) is one of the five LDH isoenzymes and, apparently, the
most important for promoting anaerobic glycolysis. LDH5 is transcriptionally regulated by the …