Current molecular combination therapies used for the treatment of breast cancer

Y Wang, A Minden - International journal of molecular sciences, 2022 - mdpi.com
Breast cancer is the second leading cause of death for women worldwide. While
monotherapy (single agent) treatments have been used for many years, they are not always …

Low-risk triple-negative breast cancers: Clinico-pathological and molecular features

N Fusco, E Sajjadi, K Venetis, M Ivanova… - Critical Reviews in …, 2022 - Elsevier
Triple-negative breast cancers (TNBC) comprise biologically and clinically heterogeneous
diseases characterized by the lack of hormone receptors (HR) and HER2 expression. This …

RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer

F Li, H Sun, Y Yu, N Che, J Han, R Cheng… - Cell Death & …, 2023 - nature.com
Necroptosis is a caspase-independent form of programmed cell death. Receptor interacting
protein kinase 1 (RIPK1) is a key molecule in the initiation of necroptosis and the formation …

Long noncoding RNAs in triple‐negative breast cancer: A new frontier in the regulation of tumorigenesis

KK Thakur, A Kumar, K Banik, E Verma… - Journal of cellular …, 2021 - Wiley Online Library
In recent years, triple‐negative breast cancer (TNBC) has emerged as the most aggressive
subtype of breast cancer and is usually associated with increased mortality worldwide. The …

The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability

Q Yang, D Yan, C Zou, Q Xue, S Lin, Q Huang… - … & Molecular Medicine, 2022 - nature.com
Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is
associated with poor prognosis, aggressive malignant behavior, and limited treatment …

The molecular landscape of breast mucoepidermoid carcinoma

K Venetis, E Sajjadi, M Ivanova, S Andaloro… - Cancer …, 2023 - Wiley Online Library
Mucoepidermoid carcinoma (MEC) of the breast is an extremely rare salivary gland‐type
tumor characterized by epidermoid, basaloid, intermediate, and/or mucinous cells arranged …

[HTML][HTML] Mitochondrial dynamics, a new therapeutic target for Triple Negative Breast Cancer

K Weiner-Gorzel, M Murphy - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Abstract Triple Negative Breast Cancer (TNBC) is an aggressive tumour with patients
survival rarely exceeding five years. TNBC tumours are larger in size, more chemoresistant …

[HTML][HTML] Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt …

C Bao, T Liu, L Qian, C Xiao, X Zhou, H Ai… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Triple-negative breast cancer (TNBC) is a great threat to global women's health
due to its high metastatic potential. Epithelial-to-mesenchymal transition (EMT) is considered …

Effective suppression of triple negative breast cancer by paclitaxel nanoparticles conjugated with transmembrane TNF-α monoclonal antibody

J Liu, P Wang, B Huang, Q Cheng, Y Duan… - International journal of …, 2022 - Elsevier
Abstract Transmembrane TNF-α (tmTNF), a transmembrane form of TNF-α, was reported
overexpressed in approximately 84% of triple-negative breast cancer (TNBC) patients and …

Clinical considerations of CDK4/6 inhibitors in triple-negative breast cancer

R Wang, K Xu, F Gao, J Huang, X Guan - Biochimica et Biophysica Acta …, 2021 - Elsevier
The formation of cyclinD-CDK4/6 complex plays vital roles in the cell cycle transition from G1
phase to S phase which is characterized by vigorous transcription and synthesis. Through …