[PDF][PDF] Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading
to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-…
to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-…
Self-healing polymeric materials
Inspired by nature, self-healing materials represent the forefront of recent developments in
materials chemistry and engineering. This review outlines the recent advances in the field of …
materials chemistry and engineering. This review outlines the recent advances in the field of …
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
N 6 -methyladenosine (m 6 A) is a chemical modification present in multiple RNA species,
being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and …
being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and …
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N6-methyladenosine (m 6 A) residues in RNA in …
demethylation activity targeting the abundant N6-methyladenosine (m 6 A) residues in RNA in …
5-methylcytosine promotes mRNA export—NSUN2 as the methyltransferase and ALYREF as an m5C reader
5-methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …
[HTML][HTML] Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment
LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - hindawi.com
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self-renew …
responsible for drug resistance and cancer relapse due in part to their ability to self-renew …
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but
ubiquitous expression causes obesity. An expressed sequence tag was identified that …
ubiquitous expression causes obesity. An expressed sequence tag was identified that …
Metal–organic framework (MOF)‐based drug/cargo delivery and cancer therapy
MX Wu, YW Yang - Advanced Materials, 2017 - Wiley Online Library
Metal–organic frameworks (MOFs)—an emerging class of hybrid porous materials built from
metal ions or clusters bridged by organic linkers—have attracted increasing attention in …
metal ions or clusters bridged by organic linkers—have attracted increasing attention in …
Is breast cancer survival improving? Trends in survival for patients with recurrent breast cancer diagnosed from 1974 through 2000
…, AU Buzdar, TL Smith, SW Kau, Y Yang… - … Journal of the …, 2004 - Wiley Online Library
BACKGROUND Despite advances in therapies for breast cancer, improvement in survival
for patients with recurrent or metastatic breast cancer has been difficult to establish. The …
for patients with recurrent or metastatic breast cancer has been difficult to establish. The …
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the
N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the …
N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the …
