Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in
the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P …

P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the
brain. We have determined the efficacy of several (putative) inhibitors of Pgp (cyclosporin A …

Oral chemotherapy has many advantages over parenteral chemotherapeutics
administration. To use the advantages of the oral chemotherapy and maximize anti-tumor …

We determined the effect of zosuquidar· 3HCl, an inhibitor of P-gp, on the penetration of the
anticancer drug paclitaxel into the brain. Zosuquidar· 3HCl was administered orally at 25 …

P-glycoprotein (Pgp) in the blood–brain barrier limits the brain's uptake of many anticancer
drugs. We have investigated whether the Pgp inhibitors cyclosporin A, valspodar (PSC833) …

Abstract P-glycoprotein (P-gp), a factor responsible for the multidrug resistance of tumors, is
specifically expressed in brain microenvironment. To test its roles in brain metastatic tumor …

Paclitaxel is not effective for treatment of brain cancers because it cannot cross the blood–
brain barrier (BBB) due to efflux by P-glycoprotein (P-gp). In this work, glutathione-coated …

HM30181, a potent and selective inhibitor of the adenosine triphosphate-binding cassette
transporter P-glycoprotein (Pgp), was shown to enhance oral bioavailability and improve …

Since P-glycoprotein (P-gp) acts as a barrier to intestinal absorption of various drugs, P-gp
inhibitors have been studied as oral absorption enhancers of P-gp substrate drugs. Here, we …

Chemotherapy of primary and secondary brain tumors is hampered by the existence of the
blood-brain-barrier (BBB) which reduce the brain concentrations of lipophilic cytostatic …