Effect of anlotinib as a third-line or further treatment on overall survival of patients with advanced non–small cell lung cancer: the ALTER 0303 phase 3 randomized …
…, J He, Y Shi, Y Zhao, H Yu, Y Zhao, W Chen… - JAMA …, 2018 - jamanetwork.com
Importance Anlotinib is a novel multitarget tyrosine kinase inhibitor for tumor angiogenesis
and proliferative signaling. A phase 2 trial showed anlotinib to improve progression-free …
and proliferative signaling. A phase 2 trial showed anlotinib to improve progression-free …
Organ-on-a-chip: a new paradigm for drug development
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells
Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …
Giant five-photon absorption from multidimensional core-shell halide perovskite colloidal nanocrystals
Multiphoton absorption processes enable many technologically important applications, such
as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher…
as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher…
Antiviral efficacies of FDA-approved drugs against SARS-CoV-2 infection in ferrets
Due to the urgent need of a therapeutic treatment for coronavirus (CoV) disease 2019 (COVID-19)
patients, a number of FDA-approved/repurposed drugs have been suggested as …
patients, a number of FDA-approved/repurposed drugs have been suggested as …
Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies
Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent
a potential alternative to invasive biopsies as a source of tumor tissue for the detection, …
a potential alternative to invasive biopsies as a source of tumor tissue for the detection, …
Ultra-thin ultra-smooth and low-loss silver films on a germanium wetting layer
We demonstrate a method to fabricate ultra-thin, ultra-smooth and low-loss silver (Ag) films
using a very thin germanium (Ge) layer as a wetting material and a rapid post-annealing …
using a very thin germanium (Ge) layer as a wetting material and a rapid post-annealing …
[PDF][PDF] Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains
unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and …
unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and …
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …
