Hepatocellular carcinoma (HCC) has become one of the major diseases that are threatening
human health in the 21st century. Currently there are many approaches to treat liver cancer…

Protein glycosylation is a common post-translational modification that has significant impacts
on protein folding, lifespan, conformation, distribution and function. N-Glycans, which are …

Permethylation is a common derivatization method for MS-based glycomic analyses.
Permethylation enhances glycan ionization efficiency in positive MS analysis and improves glycan …

The biosynthesis of glycans is a template-free process; hence compositionally identical
glycans may contain highly heterogeneous structures. Meanwhile, the functions of glycans in …

Early stage detection and cancer treatment demand the identification of reliable biomarkers.
Over the past decades, efforts have been devoted to assess the variation of glycosylation …

Oligosaccharides in milk not only provide nutrition to the infants but also have significant
immune biofunctions such as inhibition of pathogen binding to the host cell. The main …

Background Liver cancer is one of the common malignancies. The dysregulation of metabolism
is a driver of accelerated tumourigenesis. Metabolic changes are well documented to …

Antibody-drug conjugates (ADCs) are one of the fastest growing classes of anticancer therapies.
Combining the high targeting specificity of monoclonal antibodies (mAbs) with cytotoxic …

Traumatic brain injuries (TBIs) present a chief public health threat affecting nations worldwide.
As numbers of patients afflicted by TBI are expected to rise, the necessity to increase our …

Protein glycosylation plays an important role in various biological processes, such as
modification of protein function, regulation of protein–protein interactions, and control of turnover …