BACKGROUND Infertility is a major issue in human reproductive health, affecting an estimated
15% of couples worldwide. Infertility can result from disorders of sex development (DSD) …

The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that …

In this paper, we present an improved fuzzy C-means (FCM) algorithm for image segmentation
by introducing a tradeoff weighted fuzzy factor and a kernel metric. The tradeoff weighted …

Vaccines to induce effective and sustained antitumor immunity have great potential for
postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-…

Objectives To explore the possible role of n-3 polyunsaturated fatty acids (PUFAs) in lowering
inflammation markers in individuals with type 2 diabetes mellitus. Methods PubMed, CNKI …

Immune responses need to be tightly controlled to avoid excessive inflammation and prevent
unwanted host damage. Here we report that germinal center kinase MST4 responded …

Photodynamic therapy (PDT) has emerged as a promising clinical modality for cancer therapy
due to its ability to initiate an antitumor immune response. However, PDT-mediated cancer …

Concerted co-regulation of multiple signalling pathways is crucial for tissue homoeostasis
and tumorigenesis. Here we report that VGLL4, a previously identified YAP antagonist, also …

Loss of Hippo tumor-suppressor activity and hyperactivation of YAP are commonly observed
in cancers. Inactivating mutations of Hippo kinases MST1/2 are uncommon, and it remains …

A novel composite material GrO@MIL-101 was synthesized using a solvothermal synthesis
method. Then the parent materials (MIL-101 and graphene oxide) and the GrO@MIL-101 …