Measuring gene expression in individual cells is crucial for understanding the gene regulatory
network controlling human embryonic development. Here we apply single-cell RNA …

The recent emergence of B.1.1.529, the Omicron variant 1 , 2 , has raised concerns of
escape from protection by vaccines and therapeutic antibodies. A key test for potential …

Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

A new technique for remote sensing of aerosol over the land and for atmospheric correction
of Earth imagery is developed. It is based on detection of dark surface targets in the blue and …

IN mammalian cells, DNA damage increases the levels of the nuclear tumour-suppressor
p53, resulting in elevated synthesis of p21, an inhibitor of cyclin-dependent kinases (CDK) 1–6 …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development 1 , 2 , 3 , 4 , 5 . However, its dynamic patterns have not been analysed at the …

We have investigated the feedback control that prevents cells with incompletely assembled
spindles from leaving mitosis. We isolated budding yeast mutants sensitive to the anti-…

Aneuploidy, referring here to genome contents characterized by abnormal numbers of
chromosomes, has been associated with developmental defects, cancer and adaptive evolution in …

Loss of proteostasis underlies ageing and neurodegeneration characterized by the
accumulation of protein aggregates and mitochondrial dysfunction 1 , 2 , 3 , 4 , 5 . Although many …

Cell polarization can occur in the absence of any spatial cues. To investigate the mechanism
of spontaneous cell polarization, we used an assay in yeast where expression of an …