Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by …

Inorganic nanoparticles (INPs) have been paid great attention in the field of oncology in
recent past years since they have enormous potential in drug delivery, gene delivery, …

Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously
by mammalian cells. Clinical applications for exosomes remain a challenge because of their …

Infections induced by bacteria at present are a severe threat to public health. Compared
with extracellular bacteria, intracellular bacteria are harder to get rid of and readily induce …

Rationale: Developing an effective nanoplatform to realize'multi-in-one'is essential to broaden
the therapeutic potential of combination therapy. Exosomes are ideal candidates since …

Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis, …

Blood transferrin receptor-positive (TfR+) exosomes are a kind of optimized drug delivery
vector compared with other kinds of exosomes due to their easy access and high bio-safety. …

Accelerating the healing of bone fractures by local delivery of growth factors possessing
osteoinductive activity has been extensively demonstrated. Unfortunately, for some complex …

As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged
as a class of powerful therapeutics for treatment of a broad range of diseases. For central …

To date, the encapsulation of therapeutic enzymes in a protective matrix is an optimized
strategy for the maintenance of their stability, facilitating their clinical application. However, the …