Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Tor A Klingen; Ying Chen; Marian D Gundersen; Hans Aas; Bjørn Westre; Torill Sauer

doi:10.1186/1746-1596-5-37

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Diagn Pathol. 2010 Jun 17:5:37. doi: 10.1186/1746-1596-5-37.

Authors

Tor A Klingen¹, Ying Chen, Marian D Gundersen, Hans Aas, Bjørn Westre, Torill Sauer

Affiliation

¹ Department of Pathology, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway. tor.klingen@siv.no

Abstract

This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung.On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation.

Publication types

Case Reports
Review

MeSH terms

Aged
Biomarkers, Tumor / analysis*
Breast Neoplasms / chemistry*
Breast Neoplasms / diagnosis
Breast Neoplasms / pathology
Breast Neoplasms / surgery
Carcinoma, Ductal, Breast / chemistry*
Carcinoma, Ductal, Breast / diagnosis
Carcinoma, Ductal, Breast / pathology
Carcinoma, Ductal, Breast / surgery
Cell Differentiation
Female
Humans
Immunohistochemistry
Mastectomy
Neoplasm Invasiveness
Nuclear Proteins / analysis*
Positron-Emission Tomography
Thyroid Nuclear Factor 1
Tomography, X-Ray Computed
Transcription Factors / analysis*

Substances

Biomarkers, Tumor
NKX2-1 protein, human
Nuclear Proteins
Thyroid Nuclear Factor 1
Transcription Factors