Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe

Willem J M Mulder; Rolf Koole; Ricardo J Brandwijk; Gert Storm; Patrick T K Chin; Gustav J Strijkers; Celso de Mello Donegá; Klaas Nicolay; Arjan W Griffioen

doi:10.1021/nl051935m

Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe

Nano Lett. 2006 Jan;6(1):1-6. doi: 10.1021/nl051935m.

Authors

Willem J M Mulder¹, Rolf Koole, Ricardo J Brandwijk, Gert Storm, Patrick T K Chin, Gustav J Strijkers, Celso de Mello Donegá, Klaas Nicolay, Arjan W Griffioen

Affiliation

¹ Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands. w.j.m.mulder@tue.nl

PMID: 16402777
DOI: 10.1021/nl051935m

Abstract

MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alphavbeta3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Endothelial Cells / metabolism
Gadolinium DTPA
Humans
Image Enhancement*
Integrin alphaVbeta3 / metabolism*
Liposomes
Magnetic Resonance Imaging
Microscopy, Fluorescence
Molecular Probes*
Oligopeptides / metabolism*
Phosphatidylethanolamines
Polyethylene Glycols
Quantum Dots*
Umbilical Veins / cytology

Substances

Integrin alphaVbeta3
Liposomes
Molecular Probes
Oligopeptides
Phosphatidylethanolamines
gadolinium stearylamide DTPA
polyethylene glycol-distearoylphosphatidylethanolamine
Polyethylene Glycols
arginyl-glycyl-aspartic acid
Gadolinium DTPA