References
- 1 Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352(10), 987–996 (2005).
- 2 The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216), 1061–1068 (2008).
- 3 Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17(5), 510–522 (2010).
- 4 Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. J. Neurooncol. 98(1), 93–99 (2010).
- 5 Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc. Natl Acad. Sci. USA 110(10), 4009–4014 (2013).
- 6 Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc. Natl Acad. Sci. USA 109(8), 3041–3046 (2012).
- 7 . The brain tumor microenvironment. Glia 60(3), 502–514 (2012).
- 8 . The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro. Oncol. 8(3), 261–279 (2006).
- 9 . Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J. Pathol. 216(1), 15–24 (2008).
- 10 Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS ONE 7(8), e43339 (2012).
- 11 CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19(10), 1264–1272 (2013).
- 12 : Macrophage diversity enhances tumor progression and metastasis. Cell 141(1), 39–51 (2010).
- 13 . Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation. J. Neurosurg. 110(3), 572–582 (2009).
- 14 HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13(3), 206–220 (2008).
- 15 Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14(4), 299–311 (2008).
- 16 . Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. J. Neurooncol. 104(1), 83–92 (2011).
- 17 . Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J. Clin. Invest. 120(3), 694–705 (2010).
- 18 Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats. Neuro. Oncol. 16(1), 21–28 (2014).
- 19 Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1(1), 54–67 (2011).
- 20 Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol. Med. 18, 519–527 (2012).
- 21 Investigation of correlation among safety biomarkers in serum, histopathological examination, and toxicogenomics. Int. J. Toxicol. 30(3), 300–312 (2011).
- 22 Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury. Am. J. Pathol. 179(1), 240–247 (2011).
- 23 . Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3), 193–205 (2008).
- 24 . Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. J. Immunother. 35(5), 385–389 (2012).