The role of radiotherapy in the management of localized soft tissue sarcomas

Siaw Sze Tiong, Colleen Dickie, Rick L. Haas, Brian O’ Sullivan


The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in themanagement of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmarktrial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites,including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reducethe volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technologyadvances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT)and particle therapy will also be discussed.


Sarcoma; radiotherapy; retroperitoneal sarcoma; surgery; extremity sarcoma

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