Recent advances of sonodynamic therapy in cancer treatment

Guo-Yun Wan, Yang Liu, Bo-Wei Chen, Yuan-Yuan Liu, Yin-Song Wang, Ning Zhang

Abstract


Sonodynamic therapy (SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specializedchemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of atumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner.In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.

Keywords


Sonodynamic therapy; sonosensitizer; cancer; ultrasound; reactive oxygen species

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