Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Megan L. Ludwig, Andrew C. Birkeland, Rebecca Hoesli, Paul Swiecicki, Matthew E. Spector, J. Chad Brenner


Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model examplefor organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past fewdecades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an idealdisease for consideration of further treatment stratification and personalization. Here, we will discuss the important history ofLSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods forbringing stratified, personalized treatment strategies to the 21st century.


Head and neck cancer; laryngeal squamous cell carcinoma; genetics; targeted therapy; personalized medicine

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