Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Abstract

Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model examplefor organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past fewdecades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an idealdisease for consideration of further treatment stratification and personalization. Here, we will discuss the important history ofLSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods forbringing stratified, personalized treatment strategies to the 21st century.