Evolution of Proinflammatory Cytokines in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation

Yu-liang Wang, Yu Zhang, Zhi-jun Zhu, Rui-fa Han

Abstract


OBJECTIVE    To analyze the expression and levels of serum proinflammatory cytokines including tumor necrosis factor alpha (TNF-α), and interleukin (IL)-6 in patients with hepatocellular carcinoma (HCC), who received orthotopic liver transplantation (OLT).
METHODS    The blood samples of 20 consecutive HCC patients
who underwent liver transplantation were detected and analyzed for the clinical serum biochemical parameters, TNF-α and IL-6. Blood samples were drawn from the radial artery at planned time points: preoperatively, intraoperatively, and postoperatively. Levels of serum TNF-α and IL-6 were detected with enzyme-linked immunosorbent assay (ELISA).
RESULTS    The levels of serum TNF-α and IL-6 increased significantly at reperfusion phase compared with those detected preoperatively (P < 0.01), and the level of serum IL-6 remained significantly higher until the third day after the liver transplantation. There was a significant correlation between TNF-α and IL-6 (P < 0.001).
CONCLUSION    This research into the effects of the proinflammatory cytokines on liver transplantation has provided
new insights into the mechanisms of ischemia and reperfusion injury to OLT.

 


Keywords


liver transplantation, carcinoma, hepatocellular, reperfusion, cytokines.

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