Diagnosis and Treatment of Chromophobe Cell Renal Carcinoma (Report of 3 cases)

Xiaoping QI, Kaoxing LIN, Zhenjiang LI, Xiaofeng HUANG, Xiaowen DAI


OBJECTIVE  To study the diagnosis and treatment of chromophobe cell renal carcinoma (CCRC).
METHODS  Three cases of CCRC were studied by analyzing the results of an operation, by light  microscopy, immunohistochemistry,  Hale's colloidal iron staining and electronmicroscopy (EMC).
RESULTS  Doppler  ultrasonic  and  CT  features  were  not  specific. Histopathology: Grossly the tumor tissue was homogeneous,  light  brown in color with central necrotic foci;  Light microscopy: Macrocyte, fine  reticular cytoplasm with clear cell border; Hale's colloidal iron staining: positive; pos-
itive EMA, CK~9, vimentin, Ckpan, and negative S-1@0; EMC: numerous intracyto-plasmic membranous small cysts. All patients were followed  up for 14.1-31 months (19.7 months on average), one patient had lung metastasis 11 months after resection  of a G,~ tumor, two alive patients had no local  recurrences and metastases.
CONCLUSIONS  CCRC is histo-pathologically, immunohistochemically  and electron microscopically distinct from other renal cancers. Surgical tumor removal is the best way for treatment.  It is probably a type of cancer with low malignant potential and favorable prognosis.


renal carcinoma, chromophobe cell, diagnosis, treatment.


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