Expression of Angiotensin II and Aldosterone in Radiation-induced Lung Injury

Shuo Cao, Rong Wu

Abstract


Objective    Radiation-induced lung injury (RILI) is the most common, dose-limiting complication in thoracic malignancy radiotherapy. Considering its negative impact on patients and restrictions to efficacy, the mechanism of RILI was studied.
Methods    Wistar rats were locally irradiated with a single dose of 0, 16, and 20 Gy to the right half of the lung to establish a lung injury model. Two and six months after irradiation, the right half of the rat lung tissue was removed, and the concentrations of TGF-β1, angiotensin II, and aldosterone were determined via enzyme-linked immunosorbent assay.
Results    Statistical diff  erences were observed in the expression levels of angiotensin II and aldosterone between the non-irradiation and irradiation groups. Moreover, the expression level of the angiotensin II-aldosterone system increased with increasing doses, and the difference was still observed as time progressed.
Conclusions    Angiotensin II-aldosterone system has an important pathophysiological function in the progression of RILI.

Keywords


angiotensin II, aldosterone, transforming growth factor-β1, rats, lung, radiation injury

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