Relationship between Expression of CEA, E-cadherin and Liver Metastasis in Colorectal Cancer

Ning LI, Xiaobing CHEN, Xiangbin WAN, Suxia LUO, Lili HAN, Mengqiang ZHOU, Dengwen YIN, Li ZHANG


OBJECTIVE    To investigate the expression of E-cadherin and CEA in serum in colorectal carcinoma and their relationship with liver metastasis.
METHODS    CEA level was measured post-operatively by radioimmunoassay of 60 patients with colorectal cancer. Immunohistochemical analysis was used to evaluate the expression of E-cadherin.
RESULTS     In liver metastasis group, 24 patients (24/26, 92.3%) were high level of CEA, but only 9 patients in non-liver metastasis group. The difference is significant ( P  = 0.004). Expression of E-cadherin significantly correlated with differentiation, but was not associated with T stage or N stage. Liver metastatic rate in negative expression was higher than that in positive expression. And the survival analysis showed that time of liver metastasis was significant different in two groups ( P  < 0.05).
CONCLUSION    The expression of CEA in serum can be used to predict liver mestatasis of colorectal cancer after operation. E-cadherin, associated with tumor diff erentiation, is also a hopeful indicator for the prediction of liver metastasis in patients with colorectal cancer.


colorectal cancer, liver metastasis, E-cadherin, CEA.

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