HER-2, P53 and Hormonal Receptors Protein Expression as Predictive Factors in Breast Cancer Prognosis

Seyed Mohammad Rabiee Hashemi, Somayeh Rabiee Hashemi


OBJECTIVE    Breast cancer is a heterogeneous disease with vari-able biological and clinical characteristics. We conducted a study to evaluate P53, HER-2/neu and hormonal receptor expression as predictors of prognosis in breast cancer.
METHODS    In a prospective study, we recruited 81consecutive patients with primary operable breast cancer who were treated with mastectomy followed by locoregional radiotherapy or che-motherapy and studied the presence of P53, HER-2/neu and hormonal receptors (ER/PR) expression in tumor tissues by im-munohistochemical staining. Associations between these markers expression and clinical outcomes, including local and regional recurrence and metastasis were evaluated. Statistical analysis was performed with the SPSS software. 
RESULTS    The mean time of follow-up was (47.3  ±  4.6) months. Expression of P53, HER-2/neu, Estrogen receptors and progester-one receptors were observed in 31.1%, 38.5%, 31.8% and 51.7% of the patients, respectively. P53, HER-2/neu and Negative ER status were potent predictors of local-regional recurrence (P = 0.034, 0.038, 0.044, respectively). Also HER-2/neu, Negative ER and Negative PR status were strong predictors of metastasis (P  = 0.001, 0.042, 0.054, respectively). 
CONCLUSION    P53 and HER-2/neu expression and also steroid receptors status (ER/PR status) have an important role in predict-ing the outcome of breast cancer and thus may be of value in se-lecting suitable therapeutic strategy and determining prognosis in these patients.


breast cancer, HER-2/neu, P53.

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