Multi-Targeted Therapies in Non-Small Cell Lung Cancer

Kai Wang, Jin Wei

Abstract


Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signaling process leading to cancer cell proliferation and to the neoplastic phenotype supports the necessity of interfering at different stages to avoid cancer cell resistance to therapy. For this reason, new strategies for the simultaneous inhibition of multiple molecular targets are being pursued.

 


Keywords


multi-targeted therapies, non-small cell lung cancer, tyrosine kinase inhibitors, vascular endothelial growth factor receptor

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