The role and its mechanism of intermittent fasting in tumors: friend or foe?

Xu Zhao, et al.


Intermittent fasting (IF) is becoming a prevailing topic worldwide, as it can cause changes in the body’s energy metabolism processes,improve health, and affect the progression of many diseases, particularly in the circumstance of oncology. Recent research has shownthat IF can alter the energy metabolism of tumor cells, thereby inhibiting tumor growth and improving antitumor immune responses.Furthermore, IF can increase cancer sensitivity to chemotherapy and radiotherapy and reduce the side effects of these traditionalanticancer treatments. IF is therefore emerging as a promising approach to clinical cancer treatment. However, the balance betweenlong-term benefits of IF compared with the harm from insufficient caloric intake is not well understood. In this article, we review therole of IF in tumorigenesis and tumor therapy, and discuss some scientific problems that remain to be clarified, which might providesome assistance in the application of IF in clinical tumor therapy.


Intermittent fasting; energy metabolism; tumor; immune escape; immunotherapy

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