Study on Fractionated Total Body Irradiation before Hematopoietic Stem Cell Transplantation

Tong FANG, Bo LIU, Hong GAO

Abstract


OBJECTIVE   To observe the dose and the complications from total body irradiation before hematopoietic stem cell transplantation.
METHODS    This study involved 312 patients with total body irradiation before hematopoietic stem cell transplantation. They were entered into the treated research from May 1999 to October 2005. All patients had received the irradiation from 60Co of an absorbed dose rate of (5.2 ± 1.13) cGy/min. The total dose of TBI was 7~12 Gy, 1 f/d × 2 d. A high-dose rate group (≥ 10 Gy) included 139 cases and a low-dose rate group (< 10 Gy) included 173 cases.
RESULTS     The probability of acute gastrointestinal reactions in the high-dose rate group was more compared with that in the low-dose rate group. The di ff erences for other reactions, such as hematopoietic reconstitution and graft  survival rate, between the two groups were insigni fi cant. 
CONCLUSION    Using  fractional total body irradiation at a dose rate of 5 cGy/min, with a total dose of 7~12 Gy, 1 f/d × 2 d , with the lung receiving under 7.5 Gy is a safe and eff ective pretreatment for hematopoietic stem cell transplantation.

Keywords


hematopoietic stem cell, transplantation, pretreatment, total body irradiation, absorbed dose rate.

Full Text: PDF

Refbacks

  • There are currently no refbacks.



OUR FRIENDS