Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer

Yanan Li, Jingqi Xin, Yongbing Sun, et al.

Abstract


Colorectal cancer (CRC) is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity andmortality. The development of nanosized drug delivery systems has provided a new direction in CRC treatment. Among thesesystems, magnetic nanoparticle (MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging(MRI)-related cancer theranostics. At the beginning of this original review, the carcinogenesis and treatment status of CRC aresummarized. Then, diversified preparation and functionalization methods of MNPs are systematically analyzed, followed by MRIinvolvedtheranostic strategies. The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy inCRC management is the main focus. Finally, the major challenges in promoting MRI-induced precise theranostics of CRC in clinicalpractice are discussed.

Cite this article as: Li Y, Xin J, Sun Y, Han T, Zhang H, An F. Magnetic resonanceimaging-guided and targeted theranostics of colorectal cancer. Cancer BiolMed. 2020; 17: 307-327. doi: 10.20892/j.issn.2095-3941.2020.0072


Keywords


Carcinogenesis; colorectal cancer; magnetic resonance imaging; multimodal diagnosis; targeted theranostics

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