Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

Zhixian Liang, Reilly L. Kidwell, Haijing Deng, et al.

Abstract


The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the mostprevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamicregulation of RNA N6-methyladenosine (m6A) has been reported in numerous human diseases, including several cancers. Inrecent years, eukaryotic DNA N6-methyladenosine (6mA) has also been reported and implicated in cancer progression andtumorigenesis. In this review, we summarize the contributions of N6-methyladenosine modification to cancer biology andpathogenesis in the context of both RNA and DNA. We also highlight the clinical relevance of targeting these modifications as atherapeutic strategy for cancer.

Cite this article as: Liang Z, Kidwell RL, Deng H, Xie Q. EpigeneticN6-methyladenosine modification of RNA and DNA regulates cancer. CancerBiol Med. 2020; 17: 9-19. doi: 10.20892/j.issn.2095-3941.2019.0347


Keywords


N6-methyladenosine; RNA methylation; DNA methylation; cancer; therapeutic targets

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