Metabolic reprogramming in triple-negative breast cancer

Zhanyu Wang, Qianjin Jiang, Chenfang Dong

Abstract


Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing studies have focused on its genetic andmolecular characteristics. Patients diagnosed with TNBC, compared to those diagnosed with other breast cancer subtypes, haverelatively poor outcomes due to high tumor aggressiveness and lack of targeted treatment. Metabolic reprogramming, an emerginghallmark of cancer, is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands; maintain the redox balance; and furtherpromote oncogenic signaling, cell proliferation, and metastasis. Understanding the mechanisms of metabolic remodeling mayguide the design of metabolic strategies for the effective intervention of TNBC. Here, we review the metabolic reprogramming ofglycolysis, oxidative phosphorylation, amino acid metabolism, lipid metabolism, and other branched pathways in TNBC and exploreopportunities for new biomarkers, imaging modalities, and metabolically targeted therapies.

Cite this article as: Wang Z, Jiang Q, Dong C. Metabolic reprogramming intriple-negative breast cancer. Cancer Biol Med. 2020; 17: 44-59. doi: 10.20892/j.issn.2095-3941.2019.0210.


Keywords


Metabolic reprogramming; triple-negative breast cancer; aerobic glycolysis; Warburg effect; cancer stem cell; targeted therapy

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