Camptothecin-based nanodrug delivery systems

Yan Wen, Yingze Wang, Xiaoli Liu, Wei Zhang, Xinhe Xiong, Zhongxiao Han, Xingjie Liang

Abstract


The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, livercancer, and lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 (Topo 1), leading to destruction of DNA, and arecurrently being used as important chemotherapeutic agents in clinical antitumor treatment. However, the main obstacle associatedwith cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumorsite. In addition, low bioavailability, poor water solubility, and other shortcomings hinder their anticancer activity. Different fromtraditional pharmaceutical preparations, nanotechnology-dependent nanopharmaceutical preparations have become one of themain strategies for different countries worldwide to overcome drug development problems. In this review, we summarized thecurrent hotspots and discussed a variety of camptothecin-based nanodrugs for cancer therapy. We hope that through this review,more efficient drug delivery systems could be designed with potential applications in clinical cancer therapy.

Keywords


Camptothecins; nanomedicine; cancer therapy; drug delivery system

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