Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas

Lian-Qun Zhang, Xin Song, Xue-Ke Zhao, Jia Huang, Peng Zhang, Lu-Wen Wang, Hui Meng, Jian-Wei Ku, Guo-Qiang Kong, Tao Jiang, Xin-Min Li, Xiao-Long Lv, Teng Ma, Guo Yuan, Min-Jie Wu, Shou-Jia Hu, Shuang Lv, Tang-Juan Zhang, Ling-Fen Ji, Zong-Min Fan, Neng-Chao Wang, Yao-Wen Zhang, Fu-You Zhou, Li-Dong Wang

Abstract


Objective: This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) alleleat the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA andesophageal squamous cell carcinoma (ESCC).

Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidenceareas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671polymorphism. χ2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.

Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA inthe Chinese Han population (P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidenceareas for both GCA and ESCC was lower than that in low-incidence areas (P<0.001).

Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, theALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA andESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrencein China.


Keywords


Gastric cardia adenocarcinoma; rs671; ALDH2

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