Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

Viktoria V. Bekusova, Vasily M. Patsanovskii, Alexander D. Nozdrachev, Alexandr P. Trashkov, Margarita R. Artemenko, Vladimir N. Anisimov

Abstract


Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic maleWistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in theanimals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlikegrowth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase,and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changesin DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreasedtriglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreasedendophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiatedtumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effectsof MF on metabolic homeostasis are critical for preventing colon cancer.

Keywords


Colon cancer; prevention; 1,2-dimethylhydrazine; metformin; rat

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